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The elucidation of the three-dimensional structures of biomolecules is one of the mayor research projects in the future of biotechnology. Based on the sequencing information gathered by the Genomics project, the next phase of systematic research is the expression and the structural / functional analysis of the gene products in the Proteomics project. It is widely expected that the Proteomics project will have a major impact on biotechnology within the next few years. The leading technologies to elucidate the function and structures of biomolecules are spectroscopic methods, that are based on the use of stable isotopes.
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Low concentrations of stable isotopes carrying one or more additional neutrons than standard atoms, can be found in all biomolecules. With our technology the level of stable isotopes incorporated into a biomolecule is increased from below 1 percent to better than 98 percent. The labeling with stable isotopes is similar to the labeling with radioactive isotopes, but biologically harmless. Stable isotopes can be located on the atomic level by radio waves or neutrons.Therefore they are today an important tool for analytical methods like neutron scattering, NMR-Tomography, NMR- Microscopy, NMR-, Mass-, IR- and Raman-Spektroscopy. These methods are used for the analysis of the structure and dynamics of biomolecules in the fields of biology, pharmacy and medicine, which are important for the development of new drugs. |